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Berberine Side Effects in Plain Words: Stomach, Medicines and Pregnancy
Berberine can cause appetite loss, upset stomach, diarrhea, constipation and rash. It may change how some medicines are cleared by the liver, and it is not for pregnancy or nursing. Trimoryn lists 15 mg of berberine HCl, and its label says not for those groups.
Written by the Trimoryn label deskUpdated · 5 min read
Common01
What are the common side effects of berberine?
The usual ones are mild and affect the stomach: appetite loss, upset stomach, diarrhea and constipation. A rash is also listed 1.
Berberine is a bitter plant compound, and its effects in the gut are part of why stomach upset is reported. We do not know how often it happens at 15 mg, because we found no source that tested this capsule.
Stomach upset can also come from the other lines, such as the konjac fiber, which should always be taken with a full glass of water, upright, never dry. A reaction alone cannot tell you which ingredient caused it, so report the whole product to your clinician.
Mild and common
Appetite loss, upset stomach, diarrhea, constipation.
Skin
A rash has been reported.
Call a clinician
Severe or lasting symptoms, or any sign of allergy.
Medicines02
How can berberine affect medicines?
Berberine may change how the body handles drugs that are processed by certain liver enzymes. That can make those drugs weaker or stronger.
Memorial Sloan Kettering names the CYP2D6, 2C9 and 3A4 enzymes and sulfonylurea diabetes drugs, and says berberine may lower the effect of drugs processed that way 1. Many everyday medicines use those enzymes. The NCCIH also reminds us that supplements can interact with medicines 2. Only a pharmacist who sees your list can check your case.
| If you take | Why to ask |
|---|---|
| Sulfonylurea or other diabetes medicine | Blood sugar effects may stack |
| Medicines cleared by liver enzymes | The level in your body may change |
| Blood thinners | The label tells everyone on medicine to ask |
| Several prescriptions | More chances for a clash |
Pregnancy03
Is berberine safe in pregnancy or nursing?
No. The cancer center says not to take berberine if you are pregnant or breastfeeding, since it may worsen jaundice in infants 1.
The Trimoryn label also says not for anyone under 18, pregnant or nursing. If you may become pregnant, or you are not sure, ask your clinician before you use any supplement. Keep out of reach of children.
Trimoryn: 30 capsules a bottle1 capsule a day, 15 to 30 minutes before a meal · price and shipping at checkout · 60-day guarantee (confirm)
See packsIf it happens04
What should you do if you have a reaction?
Stop the product and call your clinician. For a severe reaction, call 911.
Stop and note it
Write down the date, the lot code, the symptom and any medicine you take.
Tell your clinician
Keep taking prescribed medicine unless told otherwise.
Report it
Use FDA MedWatch at 1-888-463-6332 3. See also our side effects page.
Next step05
What is the careful way to decide?
Read the label cautions first, then ask about your own medicines.
If you still want to see the formula, check the Supplement Facts page, the checkout total and the refund terms. Healthy basics come first 4.
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FAQ06
Trimoryn questions people ask
Does berberine upset an empty stomach more?
We found no source that answers this. The label says to take the capsule before a meal, so ask your clinician if you have stomach trouble.
How soon can berberine side effects start?
We found no timing data for this capsule. Stop and call if symptoms appear.
Can children take berberine?
The Trimoryn label says not for under 18, and keep out of reach of children.
Does berberine show up on a drug test?
We found no source on that. Ask your employer or clinician if testing applies to you.
Who wrote this07
Written and reviewed by
Pages built from the label, the sales page and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is the information site for a USA Authorized Trimoryn Retailer. It is not the manufacturer or the distributor named on the label. We earn money when you buy through our order links.
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